Kaori Yamada
Assistant Professor
Research Interests
- We are studying the mechanisms that regulate vascular functions, such as vascular permeability and angiogenesis.
- In angiogenesis-related diseases such as cancer and blinding eye disorders, excessive VEGF/VEGFR2 signaling leads to the formation of leaky blood vessels. Inhibiting VEGF/VEGFR2 signaling is a promising strategy for these conditions. One of our projects focuses on the trafficking of VEGFR2 by a kinesin motor moving on microtubules, which play a role in regulating vascular permeability and angiogenesis. Our novel approach to treating angiogenesis-related diseases involves targeting VEGFR2 trafficking to suppress pathological angiogenesis and vascular leakage.
- Another project investigates a glycosylated protein secreted by metastatic breast cancer cells that increases the permeability of the blood-brain barrier, facilitating brain invasion and metastasis. By elucidating the precise mechanisms involved, we aim to develop therapeutic strategies to prevent breast cancer brain metastasis.
At a Glance
- Title Assistant Professor
- College College of Medicine at Chicago - Basic Sciences
- Department Department of Pharmacology and Regenerative Medicine
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