Jan-Hendrik Spille
Assistant Professor
Research Interests
- Professor Spille’s research uses state-of-the-art fluorescence microscopy to resolve biophysical principles of structure and function in the cell nucleus. His lab works at the interface of Biology, Chemistry, and Physics. Current efforts in the lab are directed towards understanding the biophysical mechanisms by which biomolecular condensates form and regulate processes such as transcription. For this purpose, the lab develops new tools for quantitative single molecule super resolution microscopy of biomolecules. We combine these tools with quantitative live cell imaging, cell line engineering, and computational methods to resolve the organization of the cell nucleus one molecule at a time.
- Current projects:
- PHYSICS/ENGINEERING/...: Building a new microscope for single molecule and light sheet imaging. Developing strategies for single molecule imaging data analysis.
- BIO/CHEMISTRY/...: Generating plasmids and cell lines using molecular cloning and CRISPR technology.
- Other projects may be available.
At a Glance
- Title Assistant Professor
- College College of Liberal Arts and Sciences
- Department Department of Physics
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