Guy R Adami

    Email Address:
    College: Dentistry Department: Oral Medicine and Diagnostic Sciences
    Title: Associate Professor
    Office: 569F DENT M/C 838 Phone: 3129966251

    Research Interest:
    Oral cancer strikes 30,000 new patients each in the United States and most of these patients will die within 5 years. Early detection is key to survival from this disease. Our interests are in noninvasive swab based methods to detect and diagnose oral cancer based on gene expression. The goal is to prove that a miniature brush used to collect a few hundred cells from oral tissue will allow clinicians to diagnose this disease without a biopsy. We hope to have a kit that nurses, primary care physicians, dentists and hygienists can use to diagnose this disease within 5 years.

    A second area of interest linking changes in oral bacteria with systemic disease.

    Minimum time commitment in hours per week: 4

    Qualifications of a Student:
    No prerequisites except an interest in computational data analysis and computer programming or an interest in biology of disease.

    Brief Summary of what is expected from the student:
    Several areas of work are possible.

    There is a specific opportunity for a student that would like to be involved with computer based analysis of clinical data including DNA and RNA data in order to derive new diagnostics and treatments. This will be done using large amounts of patient data.

    Gene expression analysis using brush samples involves several tasks that students can be involved with depending on their interest. This includes interacting with patients in the clinic and performing quantitative PCR to measure RNA levels (gene expression) along with gene expression analysis of thousands of genes at once using large scale cDNA sequencing.

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