Guy Adami

    Email Address:
    College: Dentistry Department: Oral Medicine and Diagnostic Sciences
    Title: Associate Professor
    Office: 569F DENT M/C 838 Phone: 3129966251

    Research Interest:
    Oral cancer strikes 30,000 new patients each in the United States and most of these patients will die within 5 years. Early detection is key to survival from this disease. Our interests are in noninvasive swab based methods to detect and diagnose oral cancer based on gene expression. The goal is to prove that a miniature brush used to collect a few hundred cells from oral tissue will allow clinicians to diagnose this disease without a biopsy. We hope to have a kit that nurses, primary care physicians, dentists and hygienists can use to diagnose this disease within 5 years.

    A second area of interest is the changes that occur in mice with aging and their causes; the identification of senescent cells in vivo and how to prevent their occurrence.

    Minimum time commitment in hours per week: 4

    Qualifications of a Student:
    No prerequisites except an interest in biological science and/or biotech.

    Brief Summary of what is expected from the student:
    Several areas of work are possible.

    Gene expression analysis using brush samples involves several tasks that students can be involved with depending on their interest. This includes interacting with patients in the clinic and performing quantitative PCR to measure RNA levels (gene expression) along with gene expression analysis of thousands of genes at once using large scale cDNA sequencing.
    There is a specific opportunity for a student that would like to be involved with computer based gene expression analysis using software designed to work with large number of genes and data at once.

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